CHANGES IN TISSUE AND BLOOD POLYAMINES DURING N-BUTYL-N-(4-HYDROXYBUTYL) NITROSOAMINE-INDUCED BLADDER CARCINOGENESIS IN RATS
نویسندگان
چکیده
منابع مشابه
N - Butyl - N - ( 4 - Hydroxybutyl ) Nitrosamine in Rats and Mice Comparison of Uroplakin Expression During Urothelial Carcinogenesis Induced
http://tpx.sagepub.com/content/27/6/645 The online version of this article can be found at: DOI: 10.1177/019262339902700606 1999 27: 645 Toxicol Pathol Cohen Kumiko Ogawa, Margaret St. John, Maria Luiza De Oliveira, Lora Arnold, Tomoyuki Shirai, Tung-Tien Sun and Samuel M. N-Butyl-N-(4-Hydroxybutyl)Nitrosamine in Rats and Mice Comparison of Uroplakin Expression During Urothelial Carcinogenesis ...
متن کاملEffects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
It has been shown that the occurrence of the preneoplastic lesion, papillary or nodular hyperplasia (PN hyperplasia) in rat urinary bladder induced by carcinogens is correlated with that of cancer. Therefore, the promoting effects of chemicals in two-stage bladder carcinogenesis were judged by measuring their ability to induce PN hyperplasia in rats. Male rats were given N-butyl-N-(4-hydroxybut...
متن کاملUrinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in dogs.
Clinicopathological, radiological, and histological studies were performed on urinary bladder neoplasia induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in five adult beagle dogs and in ten adult mongrel dogs. Tumors of the urinary bladder developed in dogs given various daily doses of BBN p.o. for different periods. The latent period of tumor induction was 4 years in dogs receiving a dai...
متن کاملDNA study of bladder papillary tumours chemically induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in Fisher rats.
To examine DNA abnormalities in bladder papillary tumours induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in female rats, using image cytometric DNA analysis and cytogenetics. Thirty female rats were exposed to BBN in their drinking water for 20 weeks. One group of 10 animals served as controls. The animals exposed to BBN were killed at a rate of two per week, with the bladder being col...
متن کاملInhibition of N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder tumor in rats by alpha-difluoromethylornithine.
The therapeutic effects of alpha-difluoromethylornithine (DFMO) on rats with bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) were examined. Eight-week-old male Wistar rats were given 0.05% BBN in their drinking water for a period of 4 weeks. Therapy (0.1% DFMO in their drinking water) was started at week 4 and all rats were killed at week 60. DFMO was seen to significantl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1997
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1989.88.658